2-CHLORO-N-(6-ETHOXY-BENZOTHIAZOL-2-YL)-ACETAMIDE synthesis

5synthesis methods

Product Name:2-CHLORO-N-(6-ETHOXY-BENZOTHIAZOL-2-YL)-ACETAMIDE
CAS Number:3268-74-4
Molecular formula:C11H11ClN2O2S
Molecular Weight:270.74

94-45-1 Synthesis

94-45-1
180 suppliers
$11.00/5g

79-04-9 Synthesis

79-04-9
365 suppliers
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2-CHLORO-N-(6-ETHOXY-BENZOTHIAZOL-2-YL)-ACETAMIDE

3268-74-4
18 suppliers
$185.63/1g

Yield:3268-74-4 84%

Reaction Conditions:

with potassium carbonate in benzene;Reflux;

Steps:

5.1.3. General synthetic procedure for N-(benzo[d]thiazol-2-yl)-2-chloroacetamides (4a-k)

General procedure: Chloroacetyl chloride (0.06 mol) was added dropwise to a mixture of the appropriate 2-amino-6-Substituted benzothiazole, 3a-k (0.05 mol) and K₂CO₃ (0.06 mol) in benzene (50 mL) at room temperature. The reaction mixture was refluxed for 6-12 h, then, after cooling to room temperature, it was slowly poured into 100 mL of ice water. A solid was formed thereafter. The precipitate was separated by filtration and washed successively with water. The product was dried under vacuum to obtain 4a-k. The progress of the reaction was monitored by Thin Layer Chromatography using toluene: acetone (8:2) solvent system.

References:

Patel, Rahul V.;Patel, Paresh K.;Kumari, Premlata;Rajani, Dhanji P.;Chikhalia, Kishor H. [European Journal of Medicinal Chemistry,2012,vol. 53,p. 41 - 51] Location in patent:experimental part

156-43-4 Synthesis