ChemicalBook CAS DataBase List 2-CHLORO-N-(4-P-TOLYL-THIAZOL-2-YL)-ACETAMIDE

2-CHLORO-N-(4-P-TOLYL-THIAZOL-2-YL)-ACETAMIDE synthesis

4synthesis methods

Product Name:2-CHLORO-N-(4-P-TOLYL-THIAZOL-2-YL)-ACETAMIDE
CAS Number:6081-87-4
Molecular formula:C12H11ClN2OS
Molecular Weight:266.75

2103-91-5 Synthesis

2103-91-5
115 suppliers
$10.00/500mg

79-04-9 Synthesis

79-04-9
366 suppliers
$12.00/5g

2-CHLORO-N-(4-P-TOLYL-THIAZOL-2-YL)-ACETAMIDE

6081-87-4
31 suppliers
$57.50/250mg

Yield:6081-87-4 81%

Reaction Conditions:

with sodium acetate in acetic acid; for 6 h;Heating;

Steps:

Synthesis of 2-chloro-N-(4-(4-substituted phenyl)thiazol-2-yl) acetamides (5a-f): General procedure

General procedure: 4-(4-substituted phenyl) thiazol-2-amine (0.05 mole) wasdissolved in 25 mL glacial acetic acid containing saturated solution of sodium acetate. To this solution, chloroacetyl chloride (0.06 mole) was added with stirring. Then, the mixture was heated on water bath for 6 h, cool at room temperature, and then poured over crushed ice. The product precipitated out was then filtered, washed with water, dried,and recrystallized from ethanol to afford pure compound in satisfactory yield.

References:

Monga, Vikramdeep;Singh, Hargyan;Singh, Gurpreet [Indian Journal of Heterocyclic Chemistry,2017,vol. 27,# 1,p. 51 - 57]