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ChemicalBook CAS DataBase List 2-Bromo-6-nitrobenzoic acid
38876-67-4

2-Bromo-6-nitrobenzoic acid synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 2 h / 0 °C / Inert atmosphere
2.1: sodium hydroxide; bromine / water / 0.75 h / 0 - 45 °C / Inert atmosphere
3.1: sodium nitrite; hydrogen bromide; acetic acid / water / 0 °C / Inert atmosphere
3.2: 0 - 65 °C / Inert atmosphere

References:

Chu, John C. K.;Dalton, Derek M.;Rovis, Tomislav [Journal of the American Chemical Society,2015,vol. 137,# 13,p. 4445 - 4452]