ChemicalBook CAS DataBase List 2-Bromo-6-fluorophenol

2-Bromo-6-fluorophenol synthesis

5synthesis methods

Product Name:2-Bromo-6-fluorophenol
CAS Number:2040-89-3
Molecular formula:C6H4BrFO
Molecular Weight:191

95-56-7 Synthesis

95-56-7
301 suppliers
$9.00/5 g

2040-89-3
178 suppliers
$6.00/1g

Yield:2040-89-3 74%

Reaction Conditions:

with acetic acid;Selectfluor;eosin y in water at 20; for 6 h;Irradiation;Green chemistry;

Steps:

7 Example 7: Preparation of compound 2A-7
Add 1 mmol of 2-bromo-phenol to 4 ml of 10% acetic acid aqueous solution, add 1.5 mmol of Selectfluor, 0.05 mmol of Eosin Y, and irradiate with 12 W blue light at room temperature for 6 hours. After the reaction is complete, add a saturated NaCl aqueous solution to the reaction solution. Chloromethane extraction, the organic layer was dried over anhydrous sodium sulfate, filtered, and evaporated to dryness under reduced pressure to obtain the crude compound.The crude compound was subjected to silica gel column chromatography, with a solution of ethyl acetate and petroleum ether in a volume ratio of 1: 9 as the mobile phase, and TLC tracer was used to collect the eluent with Rf value of 0.3-0.5. The solvent was removed under reduced pressure and dried to obtain 140 mg (yield 74%) of the pure compound represented by Formula 2A-7.

References:

Zhejiang University of Technology;Zhu Qing;Liu Jiang;Dou Yandong CN110950739, 2020, A Location in patent:Paragraph 0058-0060

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367-12-4 Synthesis