ChemicalBook CAS DataBase List 2-BROMO-5-METHOXYPHENOL

2-BROMO-5-METHOXYPHENOL synthesis

12synthesis methods

Product Name:2-BROMO-5-METHOXYPHENOL
CAS Number:63604-94-4
Molecular formula:C7H7BrO2
Molecular Weight:203.03

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Yield: 93.4%

Reaction Conditions:

with water;sodium acetate in ethanol at 80; for 4 h;Temperature;

Steps:

3.3; 4.3; 5.3; 6.3
3) The result of step 2)2-bromo-5-methoxyphenyl acetate1.74 g (7.12 mmol) was put into a 100 mL three-necked flask, then 20.0 mL of ethanol was added to the flask, and finally 6.16 g (71.20 mmol) of sodium acetate and 15 mL of water were put into the flask under magnetic stirring; the water bath was heated to 80 ° C, 80 The reaction was stirred at for 4.0h.After the reaction, the reaction solution was acidified with 1 mol / L hydrochloric acid (about 17.4 mL) to a pH of 5,For the rest of the post-treatment, refer to step 3) of Example 1 to obtain 1.35 g of 2-bromo-5-methoxyphenol as pure white crystals with a yield of 93.4%.

References:

Hangzhou Maishiteng Pharmaceutical Technology Co., Ltd.;Jin Hao;Qian Chao;Gao Zhuo CN110317129, 2019, A Location in patent:Paragraph 0064; 0069-0071; 0076-0078; 0083-0085; 0090; 0091

150-19-6 Synthesis