2-Bromo-5-chloro-3-nitropyridine synthesis
- Product Name:2-Bromo-5-chloro-3-nitropyridine
- CAS Number:75806-86-9
- Molecular formula:C5H2BrClN2O2
- Molecular Weight:237.44
5409-39-2
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$6.00/250mg
75806-86-9
160 suppliers
$14.00/1g
Yield:75806-86-9 73%
Reaction Conditions:
with hydrogen bromide;bromine;sodium nitrite in water at 0 - 20; for 1 h;
Steps:
Intermediate 32b: 2-Bromo-5-chloro-3-nitropyridine
To a solution of intermediate 32a (10.0 g, 57.6 mmol) in HBr [(31 .0 mL (100%), 286.4 mmol)] at 0 00 sodium nitrite (13.8 g, 199.9 mmol) was added drop wise. To the stirred solution Br2 (10.0 mL, 197.1 mmol) was added in water and stirred at room temperature for 1 h. The reaction mixture was basified with NaHCO3 solution (pH=7) and extracted with ethyl acetate, washed with water, and dried over anhydrousNa2SO4 The solvent was removed under vacuo to yield the title product (10.0 g,73.0%) as a yellow solid.
References:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;MADANAHALLI RANGANATH RAO, Jagannath;GURRAM RANGA, Madhavan;PACHIYAPPAN, Shanmugam WO2014/202580, 2014, A1 Location in patent:Page/Page column 100
1072-98-6
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$5.00/1g
75806-86-9
160 suppliers
$14.00/1g
21427-61-2
183 suppliers
$6.00/1g
75806-86-9
160 suppliers
$14.00/1g