ChemicalBook CAS DataBase List 2-Bromo-4-fluorobenzoic acid

2-Bromo-4-fluorobenzoic acid synthesis

4synthesis methods

Product Name:2-Bromo-4-fluorobenzoic acid
CAS Number:1006-41-3
Molecular formula:C7H4BrFO2
Molecular Weight:219.01

1422-53-3 Synthesis

1422-53-3
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$5.00/5g

1006-41-3
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$6.00/5g

Yield:1006-41-3 79%

Reaction Conditions:

with carbon tetrabromide;oxygen in acetonitrile at 20; for 60 h;Irradiation;

Steps:

Arylcarboxylic Acids 1a-v; General Procedure

General procedure: CAUTION: The reaction is inherently explosive in naturebecause significant concentrations of peroxide and hydroperoxideintermediates are generated. Appropriate precautionsshould be adopted. The reaction should not be scaled up.A solution of the appropriate substrate 1 (0.5 mmol) and CBr4(0.05 mol) in anhyd MeCN (10 mL) was stirred in a roundbottomflask fitted with an O2 balloon, and irradiated externallywith a 60 W 400 nm LED at rt. When the reaction was complete(TLC), the solvent was evaporated under reduced pressure. Theresidue was purified by column chromatography (silica gel).Benzoic Acid (2a)White solid; yield: 58.6 mg (96%); mp: 120-121 °C; Rf = 0.73(50% EtOAc-PE).

References:

Li, Xiaoqing;Xu, Xiangsheng;Yan, Xiaoyu;Yan, Xinhuan;Zhang, Guofu;Zheng, Kun [Synlett,2020,vol. 31,# 3,p. 272 - 274]

59142-68-6 Synthesis