2-nitro-4-Bromo-5-fluorobenzoic acid synthesis

2synthesis methods

Product Name:2-nitro-4-Bromo-5-fluorobenzoic acid
CAS Number:1020717-99-0
Molecular formula:C7H3BrFNO4
Molecular Weight:264.01

2,4-Dibromo-5-fluorotoluene was brominated with NBS, hydrolyzed in acid to form aldehyde, and then oxidized by Jones reagent to obtain 2-nitro-4-Bromo-5-fluorobenzoic acid.

153556-42-4
258 suppliers
$10.00/1g

1020717-99-0
107 suppliers
$8.00/1g

Yield:1020717-99-0 99.5%

Reaction Conditions:

with sulfuric acid;nitric acid at 20; for 18 h;

Steps:

1.D Step D

Compound 1 (75 g, 342.5 mmol) was dissolved in sulfuric acid (500 ml) at room temperature, and nitric acid (103.8 g, 1027 mmol) was added slowly. After stirring for 18 h, the mixture was slowly poured over 3 kg of ice, stirred, filtered, washed with water and dried at 45 ° C under reduced pressure to give compound 2 (90 g, 99.5%).

References:

CN106146482,2016,A Location in patent:Paragraph 0124; 0125; 0126

452-74-4 Synthesis

452-74-4
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$17.00/25g

1020717-99-0
107 suppliers
$8.00/1g

References