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ChemicalBook CAS DataBase List 2-Amino-5-chloro-2'-fluorobenzophenone
784-38-3

2-Amino-5-chloro-2'-fluorobenzophenone synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / toluene / 20 °C
2.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 1.25 h / -40 °C / Inert atmosphere
3.1: hydrogenchloride; water / ethanol / Reflux
3.2: pH 8

References:

Cheng, Pi;Gu, Qiong;Liu, Wei;Zou, Jian-Feng;Ou, Yang-Yong;Luo, Zhong-Yong;Zeng, Jian-Guo [Molecules,2011,vol. 16,# 9,p. 7649 - 7661]

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