ChemicalBook CAS DataBase List 2,6-Dimethyl-4-aminophenol

2,6-Dimethyl-4-aminophenol synthesis

12synthesis methods

Product Name:2,6-Dimethyl-4-aminophenol
CAS Number:15980-22-0
Molecular formula:C8H11NO
Molecular Weight:137.18

4965-29-1 Synthesis

4965-29-1
23 suppliers
$45.00/50mg

15980-22-0
45 suppliers
$75.00/100 mg

Yield: 91%

Reaction Conditions:

with hydrogenchloride;tin(ll) chloride in dichloromethane;water for 16 h;Reflux;Reagent/catalyst;

Steps:

5.6. General procedure for the synthesis of the aminophenols¹⁵
General procedure: A mixture of the para-benzoquinone mono-oxime (1.26 mmol),SnCl2 (0.72 g, 3.80 mmol), 20 mL of CH2Cl2, and 0.2 mL of concentrated HCl, was heated to reflux for 16 h. The CH2Cl2 was removed under reduced pressure, and the residue was dissolved in ethyl acetate and washed with concentrated aqueous NaHCO3. The organic layer was dried over anhydrous Na2SO4 and the filtrate was concentrated under reduced pressure to afford the solid product.

References:

Uliana, Marciana P.;Servilha, Bruno M.;Alexopoulos, Olga;De Oliveira, Kleber T.;Tormena, Cláudio F.;Ferreira, Marco A.B.;Brocksom, Timothy J. [Tetrahedron,2014,vol. 70,# 39,p. 6963 - 6973]

2423-71-4 Synthesis