2,4-Thiazolidinedione synthesis
- Product Name:2,4-Thiazolidinedione
- CAS Number:2295-31-0
- Molecular formula:C3H3NO2S
- Molecular Weight:117.13
556-90-1
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$6.00/1g
2295-31-0
510 suppliers
$6.00/5g
Yield:2295-31-0 83%
Reaction Conditions:
with hydrogenchloride;ethanolReflux;
Steps:
B
B) Synthesis of 2,4-thiazolidinedione (V):; 2-Imino-thiazolidin-4-one (IV) (1Og) was hydrolyzed with 2N HCl (40ml) in ethanol (40ml). The mixture was refluxed and the reaction was monitored on TLC. The reaction mixture was cooled and neutralized with, saturated solution of sodium bicarbonate (10%). Upon neutralization the crude product, 2,4-thiazolidinedione (V) separated as solid. The crude product was recrystallized from ethanol: water (40:60) mixture. The product was dried at 60°C. Yield : 83% M. P. : 120-123°C
References:
ELDER PHARMACEUTICALS LTD;SAKHARDANDE, Rajiv WO2010/82212, 2010, A2 Location in patent:Page/Page column 28
110-89-4
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2295-31-0
510 suppliers
$6.00/5g