2-(4-FLUOROPHENYL)ISOVALERIC ACID synthesis
1synthesis methods
- Product Name:2-(4-FLUOROPHENYL)ISOVALERIC ACID
- CAS Number:51632-33-8
- Molecular formula:C11H13FO2
- Molecular Weight:196.22
Yield:51632-33-8 99%
Reaction Conditions:
Stage #1: p-Fluorophenylacetic acidwith n-butyllithium in tetrahydrofuran at 0; for 1.5 h;Inert atmosphere;
Stage #2: 2-iodo-propane in tetrahydrofuran; for 0.25 h;Inert atmosphere;
References:
Staudaher, Nicholas D.;Lovelace, Joseph;Johnson, Michael P.;Louie, Janis [Organic Syntheses,2017,vol. 94,p. 1 - 15]