2,4-Dichloro-5-[3,4,5-trimethoxybenzyl]pyrimidine synthesis

5synthesis methods

Product Name:2,4-Dichloro-5-[3,4,5-trimethoxybenzyl]pyrimidine
CAS Number:55694-05-8
Molecular formula:C14H14Cl2N2O3
Molecular Weight:329.18

Diethyl 3,4,5-trimethoxybenzyl Phosphate

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2,4-Dichloro-5-[3,4,5-trimethoxybenzyl]pyrimidine

55694-05-8
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: i-PrMgCl*LiCl / tetrahydrofuran; 1,2-dimethoxy-ethane / 4 h / 0 °C
1.2: CuBr; P(OEt)3 / 1,2-dimethoxy-ethane; tetrahydrofuran / 0.17 h / -15 °C
1.3: 81 percent / tetrabutylammonium iodide / tetrahydrofuran; 1,2-dimethoxy-ethane / 1.5 h / 60 °C
2.1: 87 percent / aq. HCl / methanol / 0.25 h / 20 °C
3.1: 86 percent / N,N-dimethylbenzenamine; POCl₃ / 1 h / 110 °C

References:

Kofink, Christiane C.;Knochel, Paul [Organic Letters,2006,vol. 8,# 18,p. 4121 - 4124]

93885-69-9 Synthesis