ChemicalBook CAS DataBase List 2,4-Dibromo-1-fluorobenzene

2,4-Dibromo-1-fluorobenzene synthesis

7synthesis methods

Product Name:2,4-Dibromo-1-fluorobenzene
CAS Number:1435-53-6
Molecular formula:C6H3Br2F
Molecular Weight:253.89

146328-85-0
282 suppliers
$6.00/1g

1435-53-6
187 suppliers
$8.00/5g

Yield:1435-53-6 89%

Reaction Conditions:

with bromine;dibromoisocyanuric acid in dichloromethane at 60; for 24 h;UV-irradiation;Temperature;

Steps:

6 EXAMPLE 6
EXAMPLE 6 Bromoisocyanurate induced radical bromodecarboxylation of (0335) arenecarboxylic acids bromoisocyanurate (0336) ArCO H ArBr (0337) ² hv (0338) [00139] A mixture of arenecarboxylic acid ArC0₂H (1 mmol), bromoisocyanurate, additive and solvent (10 mL) was stirred under fluorescent room light (FL) or warm-white 3 W LED (LL) irradiation (hv). The reaction mixture washed with 1 M aq Na₂S0₃, dried over Na₂S0₄, filtered through short neutral alumina pad and concentrated in vacuo to yield crude bromoarene ArBr. Optionally, the crude bromide was purified by chromatography on silica gel. The results are presented in Table 5.

References:

TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED;GANDELMAN, Mark;NISNEVICH, Gennady A.;KULBITSKI, Kseniya;ARTARYAN, Alexander WO2017/60905, 2017, A1 Location in patent:Paragraph 00139; 00153

FullText

2924-09-6 Synthesis