ChemicalBook CAS DataBase List 2,3-Dihydroxybenzaldehyde

2,3-Dihydroxybenzaldehyde synthesis

10synthesis methods

Product Name:2,3-Dihydroxybenzaldehyde
CAS Number:24677-78-9
Molecular formula:C7H6O3
Molecular Weight:138.12

148-53-8
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24677-78-9
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Yield:24677-78-9 87%

Reaction Conditions:

with aluminum (III) chloride;sodium iodide in acetonitrile at 80; for 18 h;

Steps:

2
Add acetonitrile (40ml) to a 100ml eggplant bottle,Aluminum trichloride (0.752g, 5.64mmol, 1.1eq),NaI (2.305 g, 15.38 mmol, 3.0 eq) and o-vanillin (0.780 g, 5.13 mmol),Heat to 80 ° C, stop stirring after 18 hours of reaction.After cooling to room temperature, it was acidified with 2 mol/L of dilute hydrochloric acid (10 ml), and extracted with ethyl acetate (50 ml × 3). The organic phase was combined and washed with saturated aqueous sodium thiosulfate (10 ml). Washed with saturated brine (10 ml), dried over anhydrous magnesium sulfate, filtered, evaporated, evaporated, evaporated. )purification,0.620 g of 2,3-dimethoxybenzaldehyde were obtained (yellow solid, yield 87%).

References:

Jingchu Institute Of Technology;Sang Dayong;Tu Xiaodong;Tian Juan CN108821955, 2018, A Location in patent:Paragraph 0021; 0022; 0025; 0026

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