2-(2-Chloro-acetylamino)-benzoic acid methyl ester synthesis
- Product Name:2-(2-Chloro-acetylamino)-benzoic acid methyl ester
- CAS Number:58915-18-7
- Molecular formula:C10H10ClNO3
- Molecular Weight:227.64
79-04-9
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134-20-3
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58915-18-7
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$95.00/500mg
Yield:58915-18-7 98%
Reaction Conditions:
with potassium carbonate in acetone at 20; for 4 h;
Steps:
1.1 Step 1: Preparation of methyl 2-(2-chloroacetamido)benzoate
Dissolve 400 mg of methyl anthranilate in 10 ml of acetone and add 438 mg of potassium carbonate.Then, 0.25 ml of 2-chloroacetyl chloride was added, and after stirring at room temperature for 4 hours,The reaction was quenched with water, extracted three times with ethyl acetate, the organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentratedColumn chromatography (petroleum ether: ethyl acetate = 95:5, V/V) gave methyl 2-(2-chloroacetamido)benzoate. White solid 590 mg (98%).
References:
CN108689946,2018,A Location in patent:Paragraph 0073; 0077; 0078; 0079
118-92-3
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58915-18-7
22 suppliers
$95.00/500mg