1H-Benzimidazol-5-ylmethanol synthesis
- Product Name:1H-Benzimidazol-5-ylmethanol
- CAS Number:106429-29-2
- Molecular formula:C8H8N2O
- Molecular Weight:148.16
15788-16-6
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106429-29-2
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$45.00/50mg
Yield:106429-29-2 77%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 65; for 48 h;Inert atmosphere;
Steps:
Preparation of compounds 7-10
Preparation of compounds 7-10
To a suspension of 2.0?g (12.3?mmol) of 1H-benzo[d]imidazole-5-carboxylic acid in 50?mL of dry THF, in inert atmosphere was added 983?mg (24,7?mmol) of LiAlH4 and stirred 48?h?at 65?°C.
The reaction mixture was poured into EtOAc/EtOH and was filtered, by evaporation to dryness 1.4?g (77%) of compound 7 was obtained.
References:
álvarez, Raquel;Gajate, Consuelo;Puebla, Pilar;Mollinedo, Faustino;Medarde, Manuel;Peláez, Rafael [European Journal of Medicinal Chemistry,2018,vol. 158,p. 167 - 183]
141-78-6
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15788-16-6
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$5.00/250mg
106429-29-2
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$45.00/50mg
304-59-6
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58842-61-8
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$85.00/250mg
106429-29-2
87 suppliers
$45.00/50mg
58842-61-8
28 suppliers
$85.00/250mg
106429-29-2
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$45.00/50mg
774486-29-2
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106429-29-2
87 suppliers
$45.00/50mg