methyl (41R,12S,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate synthesis

1synthesis methods

Product Name:methyl (41R,12S,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
CAS Number:18374-18-0
Molecular formula:C21H26N2O3
Molecular Weight:354.4427

(+)-14-diethoxycarbonyl-1α-ethyl-1,2,3,4,5,6,12,12b-octahydro-indolo-[2,3-a]-tetrahydro-pyranyl-[2,3-c]-quinolizine

300661-83-0
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methyl (41R,12S,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

18374-18-0
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methyl (41R,12R,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

58000-63-8
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: acetic acid / ethanol / 0.17 h / 20 °C
1.2: 0.17 h
1.3: 1 h / 50 °C
2.1: potassium hydroxide / ethanol; water / 1.17 h / 20 - 30 °C
2.2: 1 h / 10 - 20 °C
3.1: methanol / 5 h / 80 °C
4.1: acetic acid; sodium metabisulfite / water / 5 h / 100 °C

References:

CN109384781,2019,A

methyl (41R,12S,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate Related Search:

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