1,3-Benzenedicarboxamide, 5-(acetylamino)-N1,N3-bis[2,3-bis(acetyloxy)propyl]-2,4,6-triiodo- synthesis

5synthesis methods

Product Name:1,3-Benzenedicarboxamide, 5-(acetylamino)-N1,N3-bis[2,3-bis(acetyloxy)propyl]-2,4,6-triiodo-
CAS Number:174416-65-0
Molecular formula:C24H28I3N3O11
Molecular Weight:915.21

76801-93-9 Synthesis

5-Amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide

76801-93-9
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108-24-7
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1,3-Benzenedicarboxamide, 5-(acetylamino)-N1,N3-bis[2,3-bis(acetyloxy)propyl]-2,4,6-triiodo-

174416-65-0
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Yield:-

Reaction Conditions:

with toluene-4-sulfonic acid;acetic acid

Steps:

1 Example 1 : Acetylation of Compound B followed by deacetylation by state of art process and process of the invention to prepare Compound A.

Compound B was acetylated in a mixture of acetic anhydride and acetic acid. Paratoluene sulfonic acid (PTSA) was used as a catalyst. After acetylation, the solution was concentrated under reduced pressure, and then methanol and water was added prior to the deacetylation step. This solution (Compound B2 solution) was divided into two equal parts. One part was deacetylated according to current practice and the other part was deacetylated according to the process of the invention.

References:

WO2014/74315,2014,A1 Location in patent:Page/Page column 14

76801-93-9 Synthesis

76801-93-9
235 suppliers
$23.00/25g

108-24-7
5 suppliers
$14.00/250ML

64-19-7 Synthesis