Yield:162090-86-0 69%

Reaction Conditions:

with triethylamine in 1,2-dimethoxyethane;toluene; for 24 h;Reflux;

Steps:

General method for the synthesis of substituted 3-chlorobenzo[b]thiophene-2-carboxamides (2a-c) and3-chlorothieno[2,3-b]thiophene-2-carboxamides(17a-c)

General procedure: To a solution of 3-chlorobenzo[b]thiophene-2-carbonyl chloride 1 and 3-chlorothieno[2,3-b]thiophene-2-carbonyl chloride 16 in toluene was added dropwise asolution of corresponding amine in toluene or DMF, followed by the addition ofEt₃N. After refluxing and cooling, the obtained solid was filteredoff, washed with diluted HCl and water, and recrystallized.

References:

Aleksi?, Maja;Berto?a, Branimir;Nhili, Raja;Depauw, Sabine;Martin-Kleiner, Irena;David-Cordonnier, Marie-Hélène;Tomi?, Sanja;Kralj, Marijeta;Karminski-Zamola, Grace [European Journal of Medicinal Chemistry,2014,vol. 71,p. 267 - 281] Location in patent:supporting information