ChemicalBook CAS DataBase List 4'-Aminoacetanilide

4'-Aminoacetanilide synthesis

14synthesis methods

Product Name:4'-Aminoacetanilide
CAS Number:122-80-5
Molecular formula:C8H10N2O
Molecular Weight:150.18

64-19-7 Synthesis

64-19-7
1558 suppliers
$10.00/25ML

141-78-6 Synthesis

141-78-6
628 suppliers
$20.50/250ml

106-50-3 Synthesis

106-50-3
613 suppliers
$19.00/25g

122-80-5
263 suppliers
$36.00/25g

Yield:122-80-5 98.6%

Reaction Conditions:

with 1,4-diaza-bicyclo[2.2.2]octane at 65 - 90; for 6 h;Inert atmosphere;Time;

Steps:

1-3 Preparation of p-aminoacetanilide:
1) Add 120.00g of ethyl acetate, 32.00g of p-phenylenediamine, and 0.26g of triethylenediamine to a 250ml four-necked flask equipped with a stirring, condensation and heating system, and mix well to obtain a mixed solution; 2) Under the protection of nitrogen, heat the mixed solution to 65-90 °C, add 10.00g of acetic acid dropwise, after the addition, react at 78-82°C for 6 hours; 3) After the reaction, the temperature is lowered to 15-25 °C, and the filter cake is filtered after standing for 6.5 hours. After the filter cake is fully washed with n-butanol and dried at 80 °C in vacuum for 6 hours, 31.84g of white crystals of p-aminoacetanilide can be obtained.It can be seen from Figure 1 that the purity of p-aminoacetanilide was 99.1% by liquid phase detection, and the yield based on the weight of p-phenylenediamine was 98.6%.

References:

Zhengzhou Kekuang Biological Technology Co., Ltd.;Niu Guofeng;Liu Shuhui;Li Meixiang;Liu Bo CN112225670, 2021, A Location in patent:Paragraph 0028-0045