ChemicalBook CAS DataBase List [R-(E)]-alpha-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol

[R-(E)]-alpha-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol synthesis

7synthesis methods

Product Name:[R-(E)]-alpha-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol
CAS Number:150026-75-8
Molecular formula:C29H28ClNO2
Molecular Weight:457.99

88-67-5 Synthesis

88-67-5
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$5.00/5g

[R-(E)]-alpha-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol

150026-75-8
55 suppliers
$110.00/10mg

2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-propanol

287930-77-2
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: sulfuric acid / 24 h / Reflux
2.1: magnesium / diethyl ether / 1.5 h / 20 °C / Inert atmosphere
2.2: 1.25 h / 0 °C / Reflux
3.1: lithium acetate; tetrabutyl-ammonium chloride; lithium chloride / N,N-dimethyl acetamide / 30 h / 20 - 120 °C / Inert atmosphere
4.1: potassium tert-butylate; [((S)-PhanePhos)-((R,R)-DACH)RuCl₂]; hydrogen / tetrahydrofuran; isopropyl alcohol / 4 h / 25 °C / 4425.44 - 6000.6 Torr

References:

Bollikonda, Satyanarayana;Mohanarangam, Saravanan;Jinna, Rajender Reddy;Kandirelli, Venkata Kiran Kumar;Makthala, Laxman;Sen, Saikat;Chaplin, David A.;Lloyd, Richard C.;Mahoney, Thomas;Dahanukar, Vilas Hareshwar;Oruganti, Srinivas;Fox, Martin E. [Journal of Organic Chemistry,2015,vol. 80,# 8,p. 3891 - 3901]

676-58-4 Synthesis