(Z)-Methyl 2-ethoxy-3-((2'-(N'-(ethoxycarbonyloxy)carbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylate synthesis
- Product Name:(Z)-Methyl 2-ethoxy-3-((2'-(N'-(ethoxycarbonyloxy)carbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylate
- CAS Number:147404-82-8
- Molecular formula:C28H28N4O6
- Molecular Weight:516.55
![(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate](/CAS/GIF/147403-65-4.gif)
Yield:147404-82-8 79%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 2 h;
Steps:
2 reparation of compound 4A
Compound (3A) 9.5 g, placed in a reaction flask was added dichloromethane 100ml, 5ml of triethylamine was added dropwise 2.5 g of methyl chloroformate, the reaction at room temperature for 2 hours.Water was added to 60ml, stirring layers were separated dichloromethane layer was separated, and the aqueous layer extracted with dichloromethane, dichloromethane layers were combined, dried over anhydrous sodium sulfate, filtered, and concentrated to give the crude product was purified by solid 8.2, yield 79 %.
References:
CN103664920,2016,B Location in patent:Paragraph 0123; 0124; 0125
![Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate](/CAS/GIF/139481-44-0.gif)
139481-44-0
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