(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate synthesis

4synthesis methods

Product Name:(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate
CAS Number:147403-65-4
Molecular formula:C25H24N4O4
Molecular Weight:444.48

139481-44-0 Synthesis

Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate

139481-44-0
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(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate

147403-65-4
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Yield:147403-65-4 90%

Reaction Conditions:

with hydroxylamine hydrochloride;sodium hydrogencarbonate in N,N-dimethyl acetamide;water at 70; for 18 h;Reagent/catalyst;Temperature;Solvent;

Steps:

4

N, N-dimethylacetamide 2L,Water 16L, added to the reaction bottle,Hydroxylamine hydrochloride (3.37 kg 48.6 mol) was added,Sodium carbonate (5.15 kg 48.6 mol) was added,1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylic acid methyl ester(2 kg, 4.86 mol)70 ° C for 18 hours,Cooling, adding water 2L,Precipitation of solid,Filtration was 2-ethoxy-1-[2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl]-1H-benzimidazole-7-carboxylic acid methyl ester (1.94 g, 37.70 mol),Reference is made to Examples1HPLC conditions Purity: 98.9% Yield: 90%.

References:

CN103408500,2016,B Location in patent:Paragraph 0026; 0046-0047

139481-44-0 Synthesis

139481-44-0
327 suppliers
$9.00/5g

147404-76-0 Synthesis