(1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride synthesis
- Product Name:(1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride
- CAS Number:1360828-80-3
- Molecular formula:C9H15ClF2N2O3S
- Molecular Weight:304.74
![Cyclopropanecarboxylic acid, 1-[bis[(1,1-dimethylethoxy)carbonyl]amino]-2-formyl-, ethyl ester, (1R,2R)-](/CAS/20210111/GIF/1152134-41-2.gif)
1152134-41-2
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Yield:-
Steps:
Multi-step reaction with 4 steps
1: 2,6-dimethylpyridine; diethylamino-sulfur trifluoride / dichloromethane / 12 h / 10 - 20 °C
2: sodium hydroxide / 20 °C
3: dmap; 2,6-dimethylpyridine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / acetonitrile / 16 h / 15 - 25 °C / Large scale
4: hydrogenchloride / Isopropyl acetate; isopropyl alcohol / 40 h / 0 - 20 °C / Large scale
References:
Cink, Russell D.;Lukin, Kirill A.;Bishop, Richard D.;Zhao, Gang;Pelc, Matthew J.;Towne, Timothy B.;Gates, Bradley D.;Ravn, Matthew M.;Hill, David R.;Ding, Chen;Cullen, Steven C.;Mei, Jianzhang;Leanna, M. Robert;Henle, Jeremy;Napolitano, José G.;Nere, Nandkishor K.;Chen, Shuang;Sheikh, Ahmad;Kallemeyn, Jeffrey M. [Organic Process Research and Development,2020,vol. 24,# 2,p. 183 - 200]
![Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)-](/CAS/GIF/259217-95-3.gif)
259217-95-3
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1360828-80-3
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1152134-45-6
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1360828-80-3
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![Cyclopropanecarboxylic acid, 1-[bis[(1,1-dimethylethoxy)carbonyl]amino]-2-(difluoromethyl)-, ethyl ester, (1R,2R)-](/CAS/20210305/GIF/1152134-42-3.gif)
1152134-42-3
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1360828-80-3
65 suppliers
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