ChemicalBook CAS DataBase List Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)-

Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)- synthesis

6synthesis methods

Product Name:Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)-
CAS Number:259217-95-3
Molecular formula:C13H21NO4
Molecular Weight:255.31

(1R,2S)-1-Amino-2-ethenyl-cyclopropanecarboxylic acid ethyl ester 4-methylbenzenesulfonate

1159609-95-6
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24424-99-5 Synthesis

24424-99-5
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Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)-

259217-95-3
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$13.00/250mg

Yield: 84.6%

Reaction Conditions:

with triethylamine in dichloromethane at 20; for 17 h;

Steps:

15 synthesis of compound SM-6c
The substrate (2 g, 6.1 mmol)Was dissolved in anhydrous dichloromethane (24 mL),Triethylamine (0.85 mL) was slowly added,The reaction solution becomes viscous;Then Boc2O (1.4 g, 6.1 mmol) was added,The reaction solution was stirred at room temperature for 17 hours,LTC shows complete reaction.The reaction solution was transferred to a separatory funnel,Followed by water (4 mL),Saturated sodium bicarbonate solution (4 mL),And saturated brine (4 mL)The organic phase was dried over anhydrous sodium sulfate,filter,The filtrate was concentrated to give 1.84 g of a yellow oil,The column chromatography gave 1.32 g (84.6%) of pure product as a colorless oil.

References:

Tianjin Changsen Pharmaceutical Co., Ltd.;Shanghai Changsen Pharmaceutical Co., Ltd.;Wang Zhe;Wang Dong;Chen Junjie;Xu Man;Xu Haitao;Wang Xiaoguang;Fan Guoqin CN107074876, 2017, A Location in patent:Paragraph 0348; 0349; 0350; 0351

681807-59-0 Synthesis