(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide synthesis
- Product Name:(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
- CAS Number:1346133-11-6
- Molecular formula:C24H22F2N2O2
- Molecular Weight:408.44
676494-56-7
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920274-04-0
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Yield:1346133-11-6 46%
Reaction Conditions:
Stage #1: 3-fluoro-4-(4-formylphenoxy)benzamide;(2S)-2-(3-fluorophenyl)pyrrolidine in 1,2-dichloro-ethane at 20; for 20 h;Molecular sieve;
Stage #2: with sodium tris(acetoxy)borohydride;acetic acid in 1,2-dichloro-ethane at 20; for 3 h;
References:
Zhang, Ying;Yan, Qiaozhi;Zi, Guofu;Hou, Guohua [Organic Letters,2017,vol. 19,# 16,p. 4215 - 4218] Location in patent:supporting information
1073-06-9
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![Carbamic acid, N-[4-(3-fluorophenyl)-4-oxobutyl]-, 1,1-dimethylethyl ester](/CAS/20210111/GIF/1223405-24-0.gif)
1223405-24-0
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676494-55-6
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1346133-11-6
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64248-62-0
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