Yield:-

Reaction Conditions:

with chlorotriisopropylsilane;trifluoroacetic acid in waterProduct distribution / selectivity;

Steps:

88
Deprotection is performed in TFA:H₂O:TIS. When the reaction is complete, the solvents are removed by rotary evaporation and the cyclic peptide (SEQ ID NO:70) is precipitated by trituration with ether and dried in a vacuum oven. MW cal.: 1189.48; MW obs.: 1189.50.

References:

Kohn, Wayne David;Peng, Sheng-Bin;Yan, Liang Zeng US2008/300177, 2008, A1 Location in patent:Page/Page column 31