ChemicalBook CAS DataBase List Benzaldehyde, 4-[(1E)-1-[[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethyl-

Benzaldehyde, 4-[(1E)-1-[[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethyl- synthesis

9synthesis methods

Product Name:Benzaldehyde, 4-[(1E)-1-[[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethyl-
CAS Number:1230487-01-0
Molecular formula:C25H28F3NO2
Molecular Weight:431.49

Ethanone, 1-[3-ethyl-4-(hydroxymethyl)phenyl]-,O-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methyl]oxime, (1E)-

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Benzaldehyde, 4-[(1E)-1-[[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethyl-

1230487-01-0
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Yield:1230487-01-0 91%

Reaction Conditions:

with 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in acetonitrile at 81; for 4 h;

Steps:

1.11 Step 11 (0279) (0280) [00260] 4-[(1E)-1-([[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino)ethyl]-2- ethylbenzaldehyde:

Step 11 (0279) (0280) [00260] 4-[(1E)-1-([[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino)ethyl]-2- ethylbenzaldehyde: To a solution of [4-[(1E)-1-([[4-cyclohexyl-3- (trifluoromethyl)phenyl]methoxy]imino) ethyl]-2-ethylphenyl]methanol (550 mg, 1.27 mmol, 1.00 equiv.) in acetonitrile (10 mL), IBX (711 mg, 2.54 mmol, 2.00 equiv.) was added. The resulting solution was stirred for 4 h at 81 ^oC. The reaction mixture was cooled and concentrated under vacuum then diluted with ethyl acetate (30 mL). The solids were filtered out and concentrated under vacuum to afford 500 mg (91%) of 4-[(1E)-1-([[4-cyclohexyl-3- (trifluoromethyl) phenyl]methoxy]imino)ethyl]-2-ethylbenzaldehyde as an off-white solid. LC-MS: m/z = 432.10 [M+H]⁺.

References:

WO2017/120124,2017,A1 Location in patent:Paragraph 00259-00260