4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide synthesis
- Product Name:4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
- CAS Number:119018-29-0
- Molecular formula:C16H21N3O4S
- Molecular Weight:351.42
![4-{2-{[(3-Ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)-carbonyl]-amino}-ethyl}-benzenesulfonyl chloride](/CAS/GIF/119043-16-2.gif)
119043-16-2
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119018-29-0
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Yield:119018-29-0 97.8%
Reaction Conditions:
with ammonia in water at 80; for 1.5 h;
Steps:
1
120 g of chlorosulfonic acid was added to a three-necked bottle, and the compound m was added in portions. After the addition, the reaction was kept at 80 ° C for 0.5 hour. The reaction was completely monitored by TLC, and the temperature was lowered to 25 ° C. The reaction was dropped into ice water and filtered to obtain a solid. Adding solid to a solution of 200 ml of ammonia water and 100 ml of water, heating to 80 ° C for 1.5 hours, cooling to 30 ° C, adding hydrochloric acid to the reaction solution, separating the solid, filtering, washing with water, drying at 50 ° C, The obtained white solid was 25.2 g, and the purity by HPLC was 78.08%, the impurity V 7.24%, the impurity was 16.35%, and the yield was 97.8%.
References:
Weihai Disu Pharmaceutical Co., Ltd.;Disha Pharmaceutical Group Co., Ltd.;Wu Ronggui;Xue Fuzhao;Xu Keling;Wang Changde CN110092739, 2019, A Location in patent:Paragraph 0022
766-36-9
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119018-29-0
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247098-18-6
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119018-29-0
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247098-17-5
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119018-29-0
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607-97-6
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119018-29-0
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$17.00/1g