2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridin synthesis
- Product Name:2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridin
- CAS Number:117977-20-5
- Molecular formula:C11H16ClNO2
- Molecular Weight:229.7
118175-10-3
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Yield: 99%
Reaction Conditions:
with thionyl chloride in dichloromethane at 20 - 25;Product distribution / selectivity;
Steps:
4
(Reference Example 4) 2-Hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine (5.0 g (23.7 mmol)) was dissolved in dichloromethane (40 ml), and thionyl chloride (4.23 g (35.6 mmol)) was added dropwise thereto so that the temperature did not exceed 25°C. Following stirring at room temperature, disappearance of the raw materials was confirmed by TLC, and 2-chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine (6.23 g) was obtained by concentrating under a reduced pressure (yield: 99.0%).
References:
Eisai R&D Management Co., Ltd. EP1775292, 2007, A1 Location in patent:Page/Page column 13
![[4-(3-Methyoxypropoxy)-3-methyl-2-pyridinyl]methanol hydrochloride](/CAS/GIF/675198-19-3.gif)
675198-19-3
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117977-18-1
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