ChemicalBook CAS DataBase List 1-TRIMETHYLSILYL-2-PYRROLIDINONE

1-TRIMETHYLSILYL-2-PYRROLIDINONE synthesis

11synthesis methods

Product Name:1-TRIMETHYLSILYL-2-PYRROLIDINONE
CAS Number:14468-90-7
Molecular formula:C7H15NOSi
Molecular Weight:157.29

616-45-5 Synthesis

616-45-5
383 suppliers
$14.00/5g

14468-90-7
79 suppliers
$49.20/10g

Yield:-

Reaction Conditions:

with chloro-trimethyl-silane;triethylamine in toluene

Steps:

20 Preparation of 1-Trimethylsilyl-2-pyrrolidinone
Preparation of 1-Trimethylsilyl-2-pyrrolidinone Chlorotrimethylsilane (TMSCl, 56.0 mL, 441 mmol) is added dropwise to a solution of 2-pyrrolidinone (30.4 mL, 400 mmol), triethylamine (70.0 mL, 502 mmol) and toluene (400 mL) at room temperature. After stirring at room temperature with a mechanical stirrer for 20 minutes, the mixture is heated at 50° C. for 4 hours. After cooling, the mixture is diluted with hexane (300 mL) and stirred for 30 minutes at room temperature. The mixture is filtered and the filtrate concentrated. Distillation of the residue (1 mm, 68+-74° C.) gives 50.0 g (94%) of the title compound as an oil. ¹ H NMR (300 MHz, d₅ -pyridine) δ 3.17, 2.26, 1.70-1.85, 0.32.

References:

Pharmacia & Upjohn Company US5712300, 1998, A

616-45-5 Synthesis

616-45-5
383 suppliers
$14.00/5g