ChemicalBook CAS DataBase List 1-QUINOLIN-3-YLETHANONE

1-QUINOLIN-3-YLETHANONE synthesis

10synthesis methods

Product Name:1-QUINOLIN-3-YLETHANONE
CAS Number:33021-53-3
Molecular formula:C11H9NO
Molecular Weight:171.2

529-23-7
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$26.00/1g

78-93-3
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$30.80/500ml

33021-53-3
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$19.00/100mg

Yield: 29%

Reaction Conditions:

with [2,2]bipyridinyl;2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;copper diacetate in toluene at 120; for 14 h;Inert atmosphere;Sealed tube;

Steps:

33 Example 33
To a 15 mL reaction tube was added 1a (0.5 mmol, 60.5 mg)Toluene (3 mL),Cu (OAc) 2 (0.05 mmol, 9.1 mg),2,2'-bipyridine (0.25 mmol, 39.0 mg), TEMPO (1 mmol, 156.2 mg) and 2 h (0.6 mmol, 53.7 [mu] L).After vacuuming the reaction tube, the reaction tube is sealed,And the reaction was stirred in an oil bath at 120 ° C for 14 h.Stop the reaction,15 mL of dichloromethane was added,Then washed successively with water and saturated NaCl solution, and the organic phase was dried over anhydrous MgSO4.filter,Spin dry,Separation by silica gel column (petroleum ether / ethyl acetate = 5/1)To give the desired product 3l (24.8 mg, 29%).

References:

Henan Normal University;Fan Xuesen;Wang Ze;Zhang Xinying;Chen Guang CN106749238, 2017, A Location in patent:Paragraph 0105; 0106; 0107