1-METHOXY-2-NAPHTHALENEMETHANOL 98 synthesis
- Product Name:1-METHOXY-2-NAPHTHALENEMETHANOL 98
- CAS Number:76635-76-2
- Molecular formula:C12H12O2
- Molecular Weight:188.22
6039-59-4
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76635-76-2
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Yield:76635-76-2 98%
Reaction Conditions:
with diisobutylaluminium hydride in toluene at -40 - 0; for 1 h;
Steps:
(1-methoxynaphthalen-2-yl)methanol
To a solution of methyl 1-methoxynaphthalene-2-carboxylate (14.0 g, 64.7 mmol) in toluene (200 ml) was added diisobutylaluminum hydride (97 ml, 1.0 M in toluene, 97 mmol; CAS-RN:[1191- 15-7]) at -40 °C. The mixture was stirred at 0 °C for 1 h. The mixture was quenched with saturated ammonium chloride and extracted with ethyl acetate. The organic phase was washed with brine, dried and concentrated under reduced pressure. The residue was purified by flash chromatography (SiO2, petroleum ether / EtOAc gradient 10%-50%) to give 12.0 g (98 % yield) of the target compound
References:
WO2021/13978,2021,A1 Location in patent:Page/Page column 267
883-21-6
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76635-76-2
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86-48-6
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76635-76-2
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