1-Ethynyl-4-(4-pentylcyclohexyl)cyclohexanol synthesis
- Product Name:1-Ethynyl-4-(4-pentylcyclohexyl)cyclohexanol
- CAS Number:6615-24-3
- Molecular formula:C8H7NO5
- Molecular Weight:197.14
673-22-3
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Yield:6615-24-3 76%
Reaction Conditions:
with nitric acid;acetic acid at 0 - 20; for 12 h;
Steps:
1 Preparation of 2-hydroxy-4-methoxy-5-nitrobenzaldehyde
A solution of 31 ml of glacial acetic acid and 31 ml of nitric acid was placed in a 250 ml round bottom flask, and the temperature of the round bottom flask was reduced to 0 ° C. 2-hydroxy-4-methoxybenzaldehyde (8.4 g, 50 mmol ) To obtain a mixture;The mixture was allowed to react at room temperature for 12 hours and the resulting reaction system was poured into a 500 ml beaker containing 200 ml of ice-water mixture.After filtration, the solid material was washed with water and the solid was dried and crystallized under ethanol and water (1: 1, v / v) to give 8.2 g of product in 76% yield.
References:
CN105622424,2016,A Location in patent:Paragraph 0107-0110
