ChemicalBook CAS DataBase List 1-ACETYLPIPERIDIN-4-OL

1-ACETYLPIPERIDIN-4-OL synthesis

7synthesis methods

Product Name:1-ACETYLPIPERIDIN-4-OL
CAS Number:4045-22-1
Molecular formula:C7H13NO2
Molecular Weight:143.18

5382-16-1
13 suppliers
$9.00/5 g

75-36-5 Synthesis

75-36-5
581 suppliers
$17.92/100G

4045-22-1
81 suppliers
$59.00/1g

Yield: 80%

Reaction Conditions:

with triethylamine in dichloromethane at -78 - 20;

Steps:

42a.1
4-hydroxypiperidine (0.534 g, 5.3 mmol) was dissolved in methylene chloride (50 mL). The solution was cooled to -78° C. and triethylamine (1.10 mL, 7.95 mmol) was added. Acetyl chloride (0.33 mL, 4.77 mmol) was added dropwise to the mixture. The mixture was warmed to r.t., concentrated under reduced pressure and purified using silica gel chromatography (50% ethyl acetate in hexanes) to give the title compound (0.540 g, 80%) as an oil. 1H NMR (CDCl3) δ 4.05-3.90 (m, 2H), 3.75-3.65 (m, 1H), 3.25-3.05 (m, 2H), 2.25 (s, 1H), 2.05 (s, 3H), 1.90-1.75 (m, 2H), 1.60-1.40 (m, 2H).

References:

Briner, Karin;Doecke, Christopher William;Mancuso, Vincent;Martinelli, Michael John;Richardson, Timothy Ivo;Rothhaar, Roger Ryan;Shi, Qing;Xie, Chaoyu US2004/82590, 2004, A1 Location in patent:Page/Page column 40

32161-06-1 Synthesis