1-(4-NITRO-2-TRIFLUOROMETHYLPHENYL)-PIPERAZINE synthesis
- Product Name:1-(4-NITRO-2-TRIFLUOROMETHYLPHENYL)-PIPERAZINE
- CAS Number:381242-61-1
- Molecular formula:C11H12F3N3O2
- Molecular Weight:275.23
Yield:381242-61-1 86%
Reaction Conditions:
with potassium carbonate in dimethyl sulfoxide at 80; for 4 h;Inert atmosphere;
Steps:
1 Synthesis of compound 1-2a:
In a 250ml reaction flask,Compound 1-1a (2.25g, 10mmol),Anhydrous piperazine (1.29g, 15mmol) andK2CO3 (2.76g, 20mmol)Add to 20ml DMSO,Under argon protection, the reaction was stirred at 80°C for 4h.After the reaction is complete, cool to room temperature, add 100ml of water, extract with ethyl acetate (100ml×3), combine the organic layers, dry with anhydrous sodium sulfate, and evaporate under reduced pressure to obtain the crude product.Purified by column chromatography (dichloromethane: methanol = 10:1),2.36 g of yellow solid was obtained with a yield of 86%.
References:
CN112851667,2021,A Location in patent:Paragraph 0091-0095
193902-86-2
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