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5465-66-7

1-(4-bromo-2-nitrophenyl)piperidine synthesis

6synthesis methods
-

Yield:5465-66-7 99%

Reaction Conditions:

with potassium carbonate in (methylsulfinyl)methane at 100;

Steps:

4.1.6. General procedure for the preparation of compounds 11a-g and 12f-g

General procedure: Alkylamine (30mmol) and K2CO3 (4.1g, 30mmol) or CsCO3 (9.8g, 30mmol) was added to compound 10 (10mmol) in DMF or DMSO (20mL). The mixture was heated at 25-120°C for 2-12h. The reaction was diluted with H2O (200mL) and then extracted with EtOAc (200mL×2). The combined organic phases were washed with H2O (200mL×2) and brine (200mL), dried over MgSO4 and concentrated in a vacuum. The residue was purified by flash column chromatography (0-10% EtOAc in petroleum ether).

References:

Li, Jing;Wu, Fangping;Liu, Xingguo;Zou, Yake;Chen, Huixiong;Li, Zheng;Zhang, Lei [European Journal of Medicinal Chemistry,2017,vol. 140,p. 20 - 30]