ChemicalBook CAS DataBase List 4-Bromo-2-nitrophenol

4-Bromo-2-nitrophenol synthesis

13synthesis methods

Product Name:4-Bromo-2-nitrophenol
CAS Number:7693-52-9
Molecular formula:C6H4BrNO3
Molecular Weight:218

The synthesis method of 4-bromo-2-nitrophenol comprises the following steps: preparing nitric acid with a concentration of 7-8 M; dissolving p-bromophenol in dichloroethane to obtain a substrate with a concentration of 1.8-2.2 M; injecting the nitric acid and the substrate into a continuous flow reactor through two pumps respectively, mixing, controlling the temperature at 55-75°C, the reaction pressure at 0.35-0.45 MPa, and reacting for 20-30 min.

88-75-5
12 suppliers
$15.00/5mg

7693-52-9
231 suppliers
$5.00/1g

Yield:7693-52-9 100%

Reaction Conditions:

with sulfuric acid;C₂₀H₂₂Br₂N₂O₅V;dihydrogen peroxide in methanol;lithium hydroxide monohydrate at 20; for 0.583333 h;Catalytic behavior;Reagent/catalyst;Solvent;

Steps:

2.5. General procedure of the oxidative bromination reaction

General procedure: In a 10-mL round-bottom flask equipped with a magnetic stirring bar, 1 mM of the 2-nitrophenol was reacted with different amounts of the oxidant, acid, bromide source, and the vanadyl Schiff base complex in 4 mL of solvent. The content was stirred at room temperature.The progress of the reaction was monitored by GLC.

References:

Grivani, Gholamhossein;Tahmasebi, Vida;Khalaji, Aliakbar Dehno;Eigner, Václav;Du?ek, Michal [Journal of Coordination Chemistry,2014,vol. 67,# 22,p. 3664 - 3677]

80-35-3 Synthesis