1-(3-nitrophenyl)pyrrolidin-2-one synthesis

8synthesis methods

Product Name:1-(3-nitrophenyl)pyrrolidin-2-one
CAS Number:61372-79-0
Molecular formula:C10H10N2O3
Molecular Weight:206.2

616-45-5 Synthesis

616-45-5
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$14.00/25g

13331-27-6 Synthesis

13331-27-6
351 suppliers
$5.00/1g

61372-79-0
21 suppliers
$28.60/50MG

Yield:61372-79-0 95%

Reaction Conditions:

Stage #1: 2-pyrrolidinon;3-Nitrophenylboronic acidwith copper(l) iodide in dimethyl sulfoxide at 20; for 0.166667 h;
Stage #2: with tert.-butylhydroperoxide in water;dimethyl sulfoxide at 60; for 1 h;

Steps:

Typical Procedure

General procedure: Aryl boronic acid (1.0 mmol), CuI (5 mol%),amide (3.0 mmol), and DMSO (1.0 mL) were added to a reactionvial, and the mixture was stirred at room temperature for10 min. A 70% aqueous solution of TBHP (1.1 mmol) was addedto the reaction mixture dropwise over 5 min. The reaction vialwas then immersed in a preheated oil bath and the progress ofreaction was followed by TLC. Upon completion of reaction, thecooled mixture was partitioned between water and ethyl acetate.The aqueous layer was further extracted with ethyl acetate,and the combined organic layers were washed with brine,dried over Na2SO4, filtered, and concentrated in vacuo. Theresidue was purified by column chromatography on silica gel(hexane-ethyl acetate) to give the desired N-aryl lactam

References:

Bathini, Thulasiram;Rawat, Vikas Singh;Sreedhar, Bojja [Synlett,2015,vol. 26,# 10,art. no. ST-2015-D0213-L,p. 1348 - 1351] Location in patent:supporting information

616-45-5 Synthesis

616-45-5
384 suppliers
$14.00/25g

585-79-5 Synthesis