ChemicalBook CAS DataBase List 1-(3-AMINOPHENYL)PYRROLIDIN-2-ONE

1-(3-AMINOPHENYL)PYRROLIDIN-2-ONE synthesis

5synthesis methods

Product Name:1-(3-AMINOPHENYL)PYRROLIDIN-2-ONE
CAS Number:31992-43-5
Molecular formula:C10H12N2O
Molecular Weight:176.22

61372-79-0 Synthesis

61372-79-0
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$28.60/50MG

31992-43-5
37 suppliers
$42.00/500mg

Yield:31992-43-5 100%

Reaction Conditions:

with hydrogen;palladium on activated carbon in ethanol at 20; under 2585.81 Torr; for 2 h;

Steps:

2

A suspension of 1-(3-nitrophenyl)pyrrolidin-2-one (3.0 g, 15 mmol) in ethanol (50 ml) was heated until complete solution was obtained. The solution was cooled to ambient temperature then treated with 10% palladium on charcoal (150 mg) and hydrogenated at 50 psi until hydrogen uptake ceased (ca. 2 hours). The mixture was filtered through a glass microfibre filter paper (Whatman GF/A) and evaporated to dryness to give 1-(3-aminophenyl)pyrrolidin-2-one as a pale green oil (2.6 g, 100%) which was used without purification.

References:

EP1214319,2003,B1 Location in patent:Page/Page column 14

585-79-5 Synthesis