ChemicalBook CAS DataBase List 1,2-Phenylenediacetic acid

1,2-Phenylenediacetic acid synthesis

10synthesis methods

Product Name:1,2-Phenylenediacetic acid
CAS Number:7500-53-0
Molecular formula:C10H10O4
Molecular Weight:194.18

613-73-0 Synthesis

613-73-0
135 suppliers
$22.80/5g

7500-53-0
207 suppliers
$27.00/5g

Yield: 56%

Reaction Conditions:

with hydrogenchloride;waterReflux;

Steps:

3
Example No.3. Synthesis of 2,2'-(l,2-phenylene)diacetic acid.[0055] The above dinitrile was dissolved in 50 mL concentrated HC1 and refluxed for 3 h. Water (30 mL) was added and the reaction heated overnight, then cooled and washed with ether. The organic layer was extracted twice with sodium carbonate. Combined aqueous layers were acidified and extracted with ether, which was dried (MgSO₄), filtered and concentrated. The diacid was obtained as a pale yellow solid in 56% yield: mp 123 - 125 °C; 1H NMR (250 MHz, DMSO-D₆) 5 3.58 (s, 4H), 7.20 (s, 4H), 12.34 (br s, 2H); ¹³C NMR (63 MHz, DMSO-D₆) 37.1 (2C), 126.8 (2C), 130.6 (2C), 134.1 (2C), 172.4 (2C).

References:

EXXONMOBIL RESEARCH AND ENGINEERING COMPANY;DAKKA, Jihad M.;MOZELESKI, Edmund J.;BAUGH, Lisa S.;BENITEZ, Frank, M. WO2011/41349, 2011, A1 Location in patent:Page/Page column 19-20