ChemicalBook CAS DataBase List 1-(2-METHOXYPHENYL)ETHANOL

1-(2-METHOXYPHENYL)ETHANOL synthesis

10synthesis methods

Product Name:1-(2-METHOXYPHENYL)ETHANOL
CAS Number:13513-82-1
Molecular formula:C9H12O2
Molecular Weight:152.19

579-74-8 Synthesis

579-74-8
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$6.00/1g

13513-82-1
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$11.00/250mg

Yield: 100%

Reaction Conditions:

with potassium tert-butylate;1-hydrosilatrane in tetrahydrofuran;N,N-dimethyl-formamide for 48 h;

Steps:

2 General Procedure for the Reduction of Ketones
General procedure: To a 25 ml round bottom flask containing 5 ml N,N-dimethylformamide, was added 1-hydrosilatrane (0.263 g, 2.0 mmol), and ketone (1.0 mmol). The resulting solution was stirred for 1 minute, after which 1 M t-BuOK in THF (1.0 mmol, 1.0 ml) was added. Reaction mixture was allowed to stir for 30 min. Reaction was quenched with 25 ml 3 M HCl, and extracted with 30 mL ethyl acetate. Organic layer was washed with brine (50 ml×3), and dried with anhydrous sodium sulphate. After filtration, the solvent was removed under vacuum to yield product.

References:

Board of Trustees of Northern Illinois University;Adler, Marc J.;Gilbert, Thomas M.;Varjosaari, Sami E.;Skrypai, Vladislav US2017/362151, 2017, A1 Location in patent:Paragraph 0091-0092