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ChemicalBook >> CAS DataBase List >> b-AP15

b-AP15

b-AP15 price.
  • $37 - $1300
  • Product name: b-AP15
  • CAS: 1009817-63-3
  • MF: C22H17N3O6
  • MW: 419.39
  • EINECS:
  • MDL Number:MFCD26142662
  • Synonyms:b-AP15 (NSC687852);4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-, (3E,5E)-;NSC 687852 (b-AP15);LM-3077;(3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-4-piperidinone;(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one;(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-4-piperidinone;(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one
28 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Axon Medchem
  • Biosynth Carbosynth
  • BroadPharm
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product number2249AH
  • Product description(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA619221
  • Product descriptionb-AP15 98+%
  • Packaging5mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA619221
  • Product descriptionb-AP15 98+%
  • Packaging10mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA619221
  • Product descriptionb-AP15 98+%
  • Packaging25mg
  • Price$114
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4453
  • Product descriptionNSC687852(b-AP15)
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4453
  • Product descriptionNSC687852(b-AP15)
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4453
  • Product descriptionNSC687852(b-AP15)
  • Packaging50mg
  • Price$243
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4453
  • Product descriptionNSC687852(b-AP15)
  • Packaging200mg
  • Price$523
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2228
  • Product descriptionNSC687852-b-AP15 98%
  • Packaging10mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA137655
  • Product descriptionb-AP15
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA137655
  • Product descriptionb-AP15
  • Packaging50mg
  • Price$262.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-25402
  • Product descriptionNSC687852
  • Packaging25mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11324
  • Product descriptionb-AP15 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11324
  • Product descriptionb-AP15 ≥98%
  • Packaging5mg
  • Price$72
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11324
  • Product descriptionb-AP15 ≥98%
  • Packaging10mg
  • Price$127
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11324
  • Product descriptionb-AP15 ≥98%
  • Packaging25mg
  • Price$266
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2249AH (3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one 5mg $105 2021-12-16 Buy
Ambeed A619221 b-AP15 98+% 5mg $39 2021-12-16 Buy
Ambeed A619221 b-AP15 98+% 10mg $65 2021-12-16 Buy
Ambeed A619221 b-AP15 98+% 25mg $114 2021-12-16 Buy
ApexBio Technology A4453 NSC687852(b-AP15) 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A4453 NSC687852(b-AP15) 10mg $75 2021-12-16 Buy
ApexBio Technology A4453 NSC687852(b-AP15) 50mg $243 2021-12-16 Buy
ApexBio Technology A4453 NSC687852(b-AP15) 200mg $523 2021-12-16 Buy
Axon Medchem Axon2228 NSC687852-b-AP15 98% 10mg $99 2021-12-16 Buy
Biosynth Carbosynth FA137655 b-AP15 10mg $75 2021-12-16 Buy
Biosynth Carbosynth FA137655 b-AP15 50mg $262.5 2021-12-16 Buy
BroadPharm BP-25402 NSC687852 25mg $320 2021-12-16 Buy
Cayman Chemical 11324 b-AP15 ≥98% 1mg $37 2024-03-01 Buy
Cayman Chemical 11324 b-AP15 ≥98% 5mg $72 2024-03-01 Buy
Cayman Chemical 11324 b-AP15 ≥98% 10mg $127 2024-03-01 Buy
Cayman Chemical 11324 b-AP15 ≥98% 25mg $266 2024-03-01 Buy

Properties

Boiling point :670.4±55.0 °C(Predicted)
Density :1.416±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 35 mg/ml).
form :solid
pka :-1.58±0.20(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Proteasome-associated deubiquitinases (DUBs) release ubiquitin from proteasome-targeted ubiquitinated proteins, regenerating free ubiquitin. b-AP15 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs. It inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 μM. It exhibits little or no activity against several other DUBs. Through its effects on USP14 and UCHL5, b-AP15 blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia. b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells.

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