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ChemicalBook >> CAS DataBase List >> SR8278

SR8278

SR8278 price.
  • $44 - $2050
  • Product name: SR8278
  • CAS: 1254944-66-5
  • MF: C18H19NO3S2
  • MW: 361.48
  • EINECS:
  • MDL Number:MFCD18782736
  • Synonyms:SR8278;1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester;UIEBLUZPSFAFOC-UHFFFAOYSA-N;SR8278;SR-8278;SR 8278;ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate;Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate;3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-, ethyl ester;Duchenne muscular dystrophy,inhibit,metabolism,biological rhythm,Alzheimer's disease,SR-8278,SR8278,neurosurgery,Inhibitor,REV-ERBα,SR 8278,REV-ERB
19 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 10
  • 1mg
  • 5mg
  • 10MG
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number6895DK
  • Product descriptionCID53393127
  • Packaging1mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014157
  • Product descriptionSR-8278 95.00%
  • Packaging10MG
  • Price$216.3
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5606
  • Product descriptionSR8278
  • Packaging10mg
  • Price$229
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17000
  • Product descriptionSR8278 ≥90%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17000
  • Product descriptionSR8278 ≥90%
  • Packaging5mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17000
  • Product descriptionSR8278 ≥90%
  • Packaging10mg
  • Price$201
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17000
  • Product descriptionSR8278 ≥90%
  • Packaging25mg
  • Price$443
  • Updated2024-03-01
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC21691
  • Product descriptionSR8278 >98%
  • Packaging100mg
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC21691
  • Product descriptionSR8278 >98%
  • Packaging250mg
  • Price$950
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC21691
  • Product descriptionSR8278 >98%
  • Packaging1g
  • Price$1900
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number61780
  • Product descriptionSR8278
  • Packaging10mg
  • Price$625
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number61780
  • Product descriptionSR8278
  • Packaging100mg
  • Price$2050
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberS9576
  • Product descriptionSR8278 ≥98% (HPLC)
  • Packaging5mg
  • Price$161
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberS9576
  • Product descriptionSR8278 ≥98% (HPLC)
  • Packaging25mg
  • Price$387.6
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number4463
  • Product descriptionSR8278 ≥99%(HPLC)
  • Packaging10
  • Price$195
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number4463
  • Product descriptionSR8278 ≥99%(HPLC)
  • Packaging50
  • Price$818
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 6895DK CID53393127 1mg $147 2021-12-16 Buy
American Custom Chemicals Corporation API0014157 SR-8278 95.00% 10MG $216.3 2021-12-16 Buy
ApexBio Technology B5606 SR8278 10mg $229 2021-12-16 Buy
Cayman Chemical 17000 SR8278 ≥90% 1mg $44 2024-03-01 Buy
Cayman Chemical 17000 SR8278 ≥90% 5mg $109 2024-03-01 Buy
Cayman Chemical 17000 SR8278 ≥90% 10mg $201 2024-03-01 Buy
Cayman Chemical 17000 SR8278 ≥90% 25mg $443 2024-03-01 Buy
DC Chemicals DC21691 SR8278 >98% 100mg $550 2021-12-16 Buy
DC Chemicals DC21691 SR8278 >98% 250mg $950 2021-12-16 Buy
DC Chemicals DC21691 SR8278 >98% 1g $1900 2021-12-16 Buy
Medical Isotopes, Inc. 61780 SR8278 10mg $625 2021-12-16 Buy
Medical Isotopes, Inc. 61780 SR8278 100mg $2050 2021-12-16 Buy
Sigma-Aldrich S9576 SR8278 ≥98% (HPLC) 5mg $161 2024-03-01 Buy
Sigma-Aldrich S9576 SR8278 ≥98% (HPLC) 25mg $387.6 2024-03-01 Buy
Tocris 4463 SR8278 ≥99%(HPLC) 10 $195 2021-12-16 Buy
Tocris 4463 SR8278 ≥99%(HPLC) 50 $818 2021-12-16 Buy

Properties

Melting point :52-55°C
Boiling point :535.7±50.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥30mg/mL
pka :-3.20±0.40(Predicted)
form :film
color :white to tan

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P273 Avoid release to the environment.
P501 Dispose of contents/container to..…

Description

REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.