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ChemicalBook >> CAS DataBase List >> Roxadustat

Roxadustat

Roxadustat price.
  • $32 - $6800
  • Product name: Roxadustat
  • CAS: 808118-40-3
  • MF: C19H16N2O5
  • MW: 352.34
  • EINECS:813-400-2
  • MDL Number:MFCD20040519
  • Synonyms:FG-4592; 2-(4-HYDROXY-1-METHYL-7-PHENOXYISOQUINOLINE-3-CARBOXAMIDO)ACETIC ACID;[[(4-Hydroxy-1-Methyl-7-phenoxyisoquinolin-3-yl)carbonyl]aMino]acetic Acid;FG-4592/FG4592;Glycine, N-[(4-hydroxy-1-Methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-;FG-4592(ASP1517);FibroGen;2-[(4-hydroxy-1-Methyl-7-phenoxyisoquinoline-3-carbonyl)aMino]acetic acid;N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine [[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid
35 prices
Selected condition:
Brand
  • Activate Scientific
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
Package
  • 5mg
  • 10MG
  • 20mg
  • 25mg
  • 10mM(in 1mL DMSO)
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 5g
  • ManufacturerActivate Scientific
  • Product numberAS112067
  • Product descriptionRoxadustat (FG-4592) 96%
  • Packaging25mg
  • Price$209
  • Updated2021-12-16
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS112067
  • Product descriptionRoxadustat (FG-4592) 96%
  • Packaging100mg
  • Price$530
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ96601
  • Product descriptionFG-4592
  • Packaging100mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ96601
  • Product descriptionFG-4592
  • Packaging250mg
  • Price$228
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0013712
  • Product descriptionN-[(4-HYDROXY-1-METHYL-7-PHENOXY-3-ISOQUINOLINYL)CARBONYL]GLYCINE 95.00%
  • Packaging10MG
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4187
  • Product descriptionFG-4592(ASP1517)
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60208
  • Product descriptionRoxadustat(FG-4592)
  • Packaging20mg
  • Price$188
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2588
  • Product descriptionFG-4592-Roxadustat|ASP1517 99%
  • Packaging100mg
  • Price$357.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154738
  • Product descriptionRoxadustat(FG-4592) >98%
  • Packaging100mg
  • Price$414.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154738
  • Product descriptionRoxadustat(FG-4592) >98%
  • Packaging250mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154738
  • Product descriptionRoxadustat(FG-4592) >98%
  • Packaging1g
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFH32910
  • Product descriptionRoxadustat
  • Packaging25mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFH32910
  • Product descriptionRoxadustat
  • Packaging100mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFH32910
  • Product descriptionRoxadustat
  • Packaging250mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFH32910
  • Product descriptionRoxadustat
  • Packaging500mg
  • Price$325
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFH32910
  • Product descriptionRoxadustat
  • Packaging1g
  • Price$550
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Activate Scientific AS112067 Roxadustat (FG-4592) 96% 25mg $209 2021-12-16 Buy
Activate Scientific AS112067 Roxadustat (FG-4592) 96% 100mg $530 2021-12-16 Buy
AK Scientific J96601 FG-4592 100mg $144 2021-12-16 Buy
AK Scientific J96601 FG-4592 250mg $228 2021-12-16 Buy
American Custom Chemicals Corporation API0013712 N-[(4-HYDROXY-1-METHYL-7-PHENOXY-3-ISOQUINOLINYL)CARBONYL]GLYCINE 95.00% 10MG $189 2021-12-16 Buy
ApexBio Technology A4187 FG-4592(ASP1517) 10mM(in 1mL DMSO) $55 2021-12-16 Buy
Arctom CFN60208 Roxadustat(FG-4592) 20mg $188 2021-12-16 Buy
Axon Medchem Axon2588 FG-4592-Roxadustat|ASP1517 99% 100mg $357.5 2021-12-16 Buy
Biorbyt Ltd orb154738 Roxadustat(FG-4592) >98% 100mg $414.8 2021-12-16 Buy
Biorbyt Ltd orb154738 Roxadustat(FG-4592) >98% 250mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb154738 Roxadustat(FG-4592) >98% 1g $1208.7 2021-12-16 Buy
Biosynth Carbosynth FH32910 Roxadustat 25mg $75 2021-12-16 Buy
Biosynth Carbosynth FH32910 Roxadustat 100mg $140 2021-12-16 Buy
Biosynth Carbosynth FH32910 Roxadustat 250mg $225 2021-12-16 Buy
Biosynth Carbosynth FH32910 Roxadustat 500mg $325 2021-12-16 Buy
Biosynth Carbosynth FH32910 Roxadustat 1g $550 2021-12-16 Buy

Properties

Melting point :199-215°C
Boiling point :684.3±55.0 °C(Predicted)
Density :1.389
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml).
form :solid
pka :2.46±0.10(Predicted)
color :Off-white or white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChI :InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
InChIKey :YOZBGTLTNGAVFU-UHFFFAOYSA-N
SMILES :C(O)(=O)CNC(C1=C(O)C2=C(C(C)=N1)C=C(OC1=CC=CC=C1)C=C2)=O

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P501 Dispose of contents/container to..…

Description

Roxadustat is an orally administered, small molecule hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that is being developed by FibroGen, in collaboration with Astellas and AstraZeneca, for the treatment of anaemia in patients with dialysis-dependent chronic kidney disease (CKD), non-dialysis-dependent CKD and in patients with myelodysplastic syndromes.

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