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ChemicalBook >> CAS DataBase List >> 2-METHOXYESTRADIOL

2-METHOXYESTRADIOL

2-METHOXYESTRADIOL price.
  • $31 - $510
  • Product name: 2-METHOXYESTRADIOL
  • CAS: 362-07-2
  • MF: C19H26O3
  • MW: 302.41
  • EINECS:263-807-9
  • MDL Number:MFCD00010489
  • Synonyms:2-METHOXYESTRADIOL \ INHIBITOR OF CELL P ROLIFERATION AND ANGIOGENESIS;2-METHOXY-OESTRADIOL-(17BETA),(13S,17S)-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL;2-Hydroxyestradiol 2-Methyl Ether;2-Methoxy-17b-estradiol;2-Methoxyestra-1,3,5(10)-triene-3,17b-diol;NSC 659853;Panzem;2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
42 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • BroadPharm
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • CSNpharm
  • DC Chemicals
  • IsoSciences
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 1mg
  • 10
  • 20mg
  • 500mg
  • 1g
  • 50
  • 10mM(in 1mL DMSO)
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product numberX5011
  • Product description2-Methoxyestradiol
  • Packaging10mg
  • Price$46
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX5011
  • Product description2-Methoxyestradiol
  • Packaging50mg
  • Price$192
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200225
  • Product description(8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 98+%
  • Packaging10mg
  • Price$34
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200225
  • Product description(8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 98+%
  • Packaging50mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200225
  • Product description(8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 98+%
  • Packaging100mg
  • Price$162
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200225
  • Product description(8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 98+%
  • Packaging250mg
  • Price$323
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberSHG0020664
  • Product description1,3,5(10)-ESTRATRIEN-2,3,17BETA-TRIOL 2-METHYLETHER 95.00%
  • Packaging5MG
  • Price$459.67
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4188
  • Product description2-Methoxyestradiol(2-MeOE2)
  • Packaging25mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4188
  • Product description2-Methoxyestradiol(2-MeOE2)
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4188
  • Product description2-Methoxyestradiol(2-MeOE2)
  • Packaging50mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4188
  • Product description2-Methoxyestradiol(2-MeOE2)
  • Packaging100mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60329
  • Product description2-Methoxyestradiol(2-MeOE2) ≥98%
  • Packaging20mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-25393
  • Product description2-Methoxyestradiol
  • Packaging25mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-25393
  • Product description2-Methoxyestradiol
  • Packaging50mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-25393
  • Product description2-Methoxyestradiol
  • Packaging100mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13021
  • Product description2-Methoxyestradiol ≥95%
  • Packaging5mg
  • Price$31
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X5011 2-Methoxyestradiol 10mg $46 2021-12-16 Buy
AK Scientific X5011 2-Methoxyestradiol 50mg $192 2021-12-16 Buy
Ambeed A200225 (8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 98+% 10mg $34 2021-12-16 Buy
Ambeed A200225 (8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 98+% 50mg $90 2021-12-16 Buy
Ambeed A200225 (8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 98+% 100mg $162 2021-12-16 Buy
Ambeed A200225 (8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 98+% 250mg $323 2021-12-16 Buy
American Custom Chemicals Corporation SHG0020664 1,3,5(10)-ESTRATRIEN-2,3,17BETA-TRIOL 2-METHYLETHER 95.00% 5MG $459.67 2021-12-16 Buy
ApexBio Technology A4188 2-Methoxyestradiol(2-MeOE2) 25mg $50 2021-12-16 Buy
ApexBio Technology A4188 2-Methoxyestradiol(2-MeOE2) 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A4188 2-Methoxyestradiol(2-MeOE2) 50mg $110 2021-12-16 Buy
ApexBio Technology A4188 2-Methoxyestradiol(2-MeOE2) 100mg $170 2021-12-16 Buy
Arctom CFN60329 2-Methoxyestradiol(2-MeOE2) ≥98% 20mg $70 2021-12-16 Buy
BroadPharm BP-25393 2-Methoxyestradiol 25mg $100 2021-12-16 Buy
BroadPharm BP-25393 2-Methoxyestradiol 50mg $200 2021-12-16 Buy
BroadPharm BP-25393 2-Methoxyestradiol 100mg $300 2021-12-16 Buy
Cayman Chemical 13021 2-Methoxyestradiol ≥95% 5mg $31 2024-03-01 Buy

Properties

Melting point :188-190°C
Boiling point :464.4±45.0 °C(Predicted)
Density :1.178±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Room Temperature
solubility :DMSO: 10 mg/mL
form :crystalline
pka :10.29±0.60(Predicted)
color :light yellow
λmax :286nm(EtOH)(lit.)
InChIKey :CQOQDQWUFQDJMK-SSTWWWIQSA-N
CAS DataBase Reference :362-07-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

2-methoxy Estradiol (2-ME2) is a natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. Administration of 2-hydroxy estradiol (2-HE2) to rats results in formation and clearance of 2-ME2 with t? values of 7.9 and 24.9 minutes, respectively. 2-ME2 exhibits no affinity for estrogen receptors. 2-ME2 has achieved considerable attention as an anti-cancer agent acting as an angiogenesis inhibitor via the HIF-1α pathway. The levels of COMT and 2-ME2 are significantly lower in women with severe pre-eclampsia.

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