RAF709
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- $44 - $1800
- Product name: RAF709
- CAS: 1628838-42-5
- MF: C28H29F3N4O4
- MW: 542.55
- EINECS:
- MDL Number:MFCD30534393
- Synonyms:RAF709;CS-2505;RAF-709;RAF 709;Benzamide, N-[2-methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)-;N-[2-Methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)benzamide;Inhibitor,inhibit,Raf,Raf kinases,RAF709,RAF-709,RAF 709;N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide
12 prices
Selected condition：
Brand
- AK Scientific
- Axon Medchem
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number3613EB
- Product descriptionN-[6-Methyl-5-[5-morpholin-4-yl-6-(oxan-4-yloxy)pyridin-3-yl]pyridin-3-yl]-3-(trifluoromethyl)benzamide
- Packaging10mg
- Price$455
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2817
- Product descriptionRAF709 99%
- Packaging50mg
- Price$462
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23820
- Product descriptionRAF709 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23820
- Product descriptionRAF709 ≥98%
- Packaging5mg
- Price$172
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23820
- Product descriptionRAF709 ≥98%
- Packaging10mg
- Price$321
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-6074
- Product descriptionRAF709 99.91%
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6074
- Product descriptionRAF709 99.91%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6074
- Product descriptionRAF709 99.91%
- Packaging25mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6074
- Product descriptionRAF709 99.91%
- Packaging50mg
- Price$490
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6074
- Product descriptionRAF709 99.91%
- Packaging100mg
- Price$790
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC9987
- Product descriptionRAF709 >98%
- Packaging100mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC9987
- Product descriptionRAF709 >98%
- Packaging1g
- Price$1800
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3613EB | N-[6-Methyl-5-[5-morpholin-4-yl-6-(oxan-4-yloxy)pyridin-3-yl]pyridin-3-yl]-3-(trifluoromethyl)benzamide | 10mg | $455 | 2021-12-16 | Buy |
| Axon Medchem | Axon2817 | RAF709 99% | 50mg | $462 | 2021-12-16 | Buy |
| Cayman Chemical | 23820 | RAF709 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 23820 | RAF709 ≥98% | 5mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 23820 | RAF709 ≥98% | 10mg | $321 | 2024-03-01 | Buy |
| ChemScene | CS-6074 | RAF709 99.91% | 5mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-6074 | RAF709 99.91% | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-6074 | RAF709 99.91% | 25mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-6074 | RAF709 99.91% | 50mg | $490 | 2021-12-16 | Buy |
| ChemScene | CS-6074 | RAF709 99.91% | 100mg | $790 | 2021-12-16 | Buy |
| DC Chemicals | DC9987 | RAF709 >98% | 100mg | $500 | 2021-12-16 | Buy |
| DC Chemicals | DC9987 | RAF709 >98% | 1g | $1800 | 2021-12-16 | Buy |
Properties
Boiling point :622.7±55.0 °C(Predicted)
Density :1.321±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:100.0(Max Conc. mg/mL);184.31(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.61(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);55.29(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);184.31(Max Conc. mM) form :A crystalline solid
pka :11.87±0.70(Predicted)
color :White to off-white
Density :1.321±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:100.0(Max Conc. mg/mL);184.31(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.61(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);55.29(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);184.31(Max Conc. mM) form :A crystalline solid
pka :11.87±0.70(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
RAF709 is a potent inhibitor of B-RAF and C-RAF (IC50s = 0.4 and 0.5 nM, respectively). It is selective for RAF kinases exhibiting >99% inhibition of only B-RAF, B-RAFV600E, and C-RAF in a panel of 456 kinases. However, DDR1, DDR2, FRK, and PDGFRβ are also inhibited by >80% at a concentration of 1 μM. RAF709 inhibits phosphorylation of MEK and ERK (EC50s = 0.02 and 0.1 μM, respectively) with minimal paradoxical activation, stabilizes BRAF-CRAF dimers (EC50 = 0.8 μM), and reduces proliferation of Calu-6 RAS mutant cells (EC50 = 0.95 μM). In a Calu-6 mouse non-small cell lung cancer (NSCLC) xenograft model, RAF709 (10-200 mg/kg) reduces ERK phosphorylation and decreases tumor volume in a dose-dependent manner without affecting total body weight.Related product price
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