R-406
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- $28 - $5180
- Product name: R-406
- CAS: 841290-80-0
- MF: C22H23FN6O5
- MW: 470.45
- EINECS:617-533-5
- MDL Number:MFCD09970820
- Synonyms:R-406;6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one ;6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one;6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;R406(free base);R-406 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one;R406 (free base), >=98%;R406 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
33 prices
Selected condition：
Brand
- Adipogen Life Sciences
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 10mg
- 25mg
- 2x25mg
- 100mg
- 250mg
- 1g
- 1mg
- 1unit
- 5MG
- 50MG
- 500MG
- 10mM(in 1mL DMSO)
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1121-M001
- Product descriptionR406 ≥95%
- Packaging1mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000332
- Product descriptionR-406 95.00%
- Packaging1MG
- Price$173.25
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0415476
- Product description6-[[5-FLUORO-2-[(3,4,5-TRIMETHOXYPHENYL)AMINO]-4-PYRIMIDINYL]AMINO]-2,2-DIMETHYL-2H-PYRIDO[3,2-B]-1,4-OXAZIN-3(4H)-ONE 95.00%
- Packaging5MG
- Price$502.11
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000332
- Product descriptionR-406 95.00%
- Packaging50MG
- Price$750.75
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000332
- Product descriptionR-406 95.00%
- Packaging500MG
- Price$1963.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5880
- Product descriptionR406(freebase)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5880
- Product descriptionR406(freebase)
- Packaging5mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5880
- Product descriptionR406(freebase)
- Packaging10mM(in 1mL DMSO)
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5880
- Product descriptionR406(freebase)
- Packaging25mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5880
- Product descriptionR406(freebase)
- Packaging100mg
- Price$1000
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60209
- Product descriptionR406freebase ≥98%
- Packaging10mg
- Price$348
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1674
- Product descriptionR406 98%
- Packaging5mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1674
- Product descriptionR406 98%
- Packaging25mg
- Price$264
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1674
- Product descriptionR406 98%
- Packaging2x25mg
- Price$396
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146065
- Product descriptionR406 free base >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146065
- Product descriptionR406 free base >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1121-M001 | R406 ≥95% | 1mg | $108 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000332 | R-406 95.00% | 1MG | $173.25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0415476 | 6-[[5-FLUORO-2-[(3,4,5-TRIMETHOXYPHENYL)AMINO]-4-PYRIMIDINYL]AMINO]-2,2-DIMETHYL-2H-PYRIDO[3,2-B]-1,4-OXAZIN-3(4H)-ONE 95.00% | 5MG | $502.11 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000332 | R-406 95.00% | 50MG | $750.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000332 | R-406 95.00% | 500MG | $1963.5 | 2021-12-16 | Buy |
| ApexBio Technology | A5880 | R406(freebase) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A5880 | R406(freebase) | 5mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | A5880 | R406(freebase) | 10mM(in 1mL DMSO) | $185 | 2021-12-16 | Buy |
| ApexBio Technology | A5880 | R406(freebase) | 25mg | $400 | 2021-12-16 | Buy |
| ApexBio Technology | A5880 | R406(freebase) | 100mg | $1000 | 2021-12-16 | Buy |
| Arctom | CFN60209 | R406freebase ≥98% | 10mg | $348 | 2021-12-16 | Buy |
| Axon Medchem | Axon1674 | R406 98% | 5mg | $88 | 2021-12-16 | Buy |
| Axon Medchem | Axon1674 | R406 98% | 25mg | $264 | 2021-12-16 | Buy |
| Axon Medchem | Axon1674 | R406 98% | 2x25mg | $396 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146065 | R406 free base >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146065 | R406 free base >98% | 250mg | $912.9 | 2021-12-16 | Buy |
Properties
Melting point :182-184°C
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :10.63±0.40(Predicted)
color :Off-White to Light Grey
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :10.63±0.40(Predicted)
color :Off-White to Light Grey
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | ||||||||||||||||||||||||
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Description
R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.More related product prices
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