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ChemicalBook >> CAS DataBase List >> PRL-3 INHIBITOR I

PRL-3 INHIBITOR I

PRL-3 INHIBITOR I price.
  • $32 - $663.07
  • Product name: PRL-3 INHIBITOR I
  • CAS: 893449-38-2
  • MF: C17H11Br2NO2S2
  • MW: 485.21
  • EINECS:
  • MDL Number:MFCD11045303
  • Synonyms:PRL-3 INHIBITOR I;Phosphatase of regenerating liver-3, Inhibitor I, 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone;5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone;Phosphatase of regenerating liver-3, Inhibitor I;PRL-3 Inhibitor;PRL-3 Inhibitor - CAS 893449-38-2 - Calbiochem;5-(5-Bromo-2-((2-bromobenzyl)oxy)benzylidene)-2-thioxothiazolidin-4-one;P0180
13 prices
Selected condition:
Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000809
  • Product descriptionPRL-3 INHIBITOR I 95.00%
  • Packaging5MG
  • Price$663.07
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3996
  • Product descriptionPRL-3Inhibitor
  • Packaging5mg
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3996
  • Product descriptionPRL-3Inhibitor
  • Packaging10mg
  • Price$208
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3996
  • Product descriptionPRL-3Inhibitor
  • Packaging25mg
  • Price$477
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon3436
  • Product descriptionPRL-3inhibitor-BR1 98%
  • Packaging10mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18719
  • Product descriptionPRL-3 Inhibitor ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18719
  • Product descriptionPRL-3 Inhibitor ≥98%
  • Packaging5mg
  • Price$70
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18719
  • Product descriptionPRL-3 Inhibitor ≥98%
  • Packaging10mg
  • Price$122
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18719
  • Product descriptionPRL-3 Inhibitor ≥98%
  • Packaging25mg
  • Price$267
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberP0108
  • Product descriptionPRL-3 Inhibitor I ≥98% (HPLC), solid
  • Packaging5mg
  • Price$105
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberB680650
  • Product description5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberB680650
  • Product description5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone
  • Packaging25mg
  • Price$335
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number349626
  • Product descriptionPRL-3 Inhibitor
  • Packaging1mg
  • Price$247
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation INB0000809 PRL-3 INHIBITOR I 95.00% 5MG $663.07 2021-12-16 Buy
ApexBio Technology C3996 PRL-3Inhibitor 5mg $112 2021-12-16 Buy
ApexBio Technology C3996 PRL-3Inhibitor 10mg $208 2021-12-16 Buy
ApexBio Technology C3996 PRL-3Inhibitor 25mg $477 2021-12-16 Buy
Axon Medchem Axon3436 PRL-3inhibitor-BR1 98% 10mg $99 2021-12-16 Buy
Cayman Chemical 18719 PRL-3 Inhibitor ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 18719 PRL-3 Inhibitor ≥98% 5mg $70 2024-03-01 Buy
Cayman Chemical 18719 PRL-3 Inhibitor ≥98% 10mg $122 2024-03-01 Buy
Cayman Chemical 18719 PRL-3 Inhibitor ≥98% 25mg $267 2024-03-01 Buy
Sigma-Aldrich P0108 PRL-3 Inhibitor I ≥98% (HPLC), solid 5mg $105 2024-03-01 Buy
TRC B680650 5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone 5mg $80 2021-12-16 Buy
TRC B680650 5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone 25mg $335 2021-12-16 Buy
Usbiological 349626 PRL-3 Inhibitor 1mg $247 2021-12-16 Buy

Properties

Density :1.85±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: >10mg/mL
form :Yellow solid
pka :7.11±0.50(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501 Dispose of contents/container to..…

Description

Phosphatase of regenerating liver 3 (PRL-3; also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases. It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin β1 and modulates VEGF-mediated endothelial cell migration. It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines.

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